Study summary · research use only
Effects of epithalon on activities gastrointestinal enzymes in young and old rats
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This rat study, using male and female Wistar rats aged 3 and 11 months, examined oral Epithalon administration and its association with activity of gastrointestinal enzymes that hydrolyze carbohydrates, proteins, and phosphoric acid esters across gut regions. The most pronounced enzyme activation was observed in 11-month-old animals. This pattern reduced the difference in enzyme activities between young and old rats compared to untreated animals. The authors state Epithalon modulates gastrointestinal enzyme activity during aging.
Abstract
Peroral administration of Epithalon (Ala-Glu-Asp-Gly) to male and female Wistar rats aging 3 and 11 months changed activity of enzymes hydrolyzing carbohydrates, proteins, and phosphoric acid esters in various portions of the gastrointestinal tract. The most pronounced activation of enzymes was observed in 11-month-old animals. This effect diminished the differences in enzyme activities between young and old rats (compared to untreated animals). Our results indicate that Epithalon modulates activity of gastrointestinal enzymes during aging.
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