Study summary · research use only
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study combined a rat model (Campbell rats with congenital pigmented retinal degeneration) and human patients with degenerative retinal lesions, examining the tetrapeptide Epitalon (Ala-Glu-Asp-Gly). In rats, Epitalon application was associated with increased bioelectric and functional retinal activity attributed to preservation of retinal structure. In patients treated with Epitalon, the authors reported a positive clinical outcome in 90% of cases. The authors suggest Epitalon may act on transcriptional mechanisms shared by the pineal gland and retina.
Abstract
We have studied the effect of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) on the course of congenital pigmented degeneration of the retina. The application of Epitalon in Campbell rats is found to intensify the bioelectric and functional activity of the retina due to the preservation of its morphological structure. Epitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases. The analysis of Epitalon effects suggests that the tetrapeptide participates in the mechanisms of transcription common for the epiphysis and retina.
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