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Study summary · research use only

[Use of thymogen in the treatment of various forms of acute abdominal disorders in an experiment]

Study · animal · Patologicheskaia fiziologiia i eksperimental'naia terapiia · 1998 · PMID 9542399

Plain-language summary

Paraphrased from the published abstract below — not a verdict on whether anything works.

In this study using white albino male rats, the abstract examined thymogen on the course of acute pancreatitis and acute peritonitis. The preparation was introduced into the abdominal cavity early after modeling and every 24 hours for 5 days. The abstract reports that in the experimental group the degree of autoenzyme aggression (blood serum alpha-amylolytic activity) and lipid peroxidation products (malonic dialdehyde in tissue homogenate) were low compared with untreated animals, depression of antiradical activity (superoxide dismutase and catalase) was less pronounced, and leukocytosis and leukocyte intoxication index were diminished. The authors describe these as demonstrating thymogen's effect in acute inflammatory and destructive abdominal disease.

Abstract

The authors have carried out experimental studies of thymogen action on the course of acute pancreatitis and acute peritonitis in white albino rat males. The preparation was introduced into the abdominal cavity early after the modeling and every 24 hours for 5 days. The results of the trial demonstrate that the degree of autoenzyme aggression (the data of blood serum alpha-amylolytic activity control) and the content of lipid peroxidation products (assessment of malonic dialdehyde quantity in tissue homogenate) were low in the experimental group as compared to the untreated animals. In the experimental group less pronounced depression of antiradical activity (superoxide dismutase and catalase activity control) was found, leukocytosis and leukocyte intoxication index were diminished. Thus, the efficiency of thymogen in acute inflammatory and destructive abdominal diseases has been proved.

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