Study summary · research use only
[The effect of thymogen on the chromosome aberration level in a culture of human peripheral blood lymphocytes]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This in vitro study examined the influence of thymogene on spontaneous and formaldehyde-induced chromosome aberrations in human peripheral blood lymphocytes. The abstract reports that high thymogene concentrations (1000, 100, and 10 micrograms/ml) significantly decreased the proliferative activity of lymphocytes, while low concentrations (1.0; 0.1; 0.01; and 0.001 microgram/ml) did not decrease mitotic activity and had no mutagenic activity. Thymogene concentrations of 1.0; 0.1; and 0.001 microgram/ml significantly decreased the frequency of formaldehyde-induced chromosome aberrations. The authors discuss possible mechanisms of gene protection by thymogene.
Abstract
The influence of thymogene on the frequency of spontaneous and formaldehyde-induced chromosome aberrations in human peripheral blood lymphocytes was detected. High thymogene concentration (1000, 100, and 10 micrograms/ml) significantly decreased the proliferative activity of lymphocytes in culture. Low thymogene concentrations (1.0; 0.1; 0.01; and 0.001 microgram/ml) didn't decrease the mitotic activity of culture and hadn't mutagenic activity. Thymogene concentrations 1.0; 0.1; and 0.001 microgram/ml significantly decreased the frequency of formaldehyde-induced chromosome aberrations in lymphocytes. Possible mechanisms of gene protection by thymogene is discussed.
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