Study summary · research use only
GHRP-2, GHRH and SRIF interrelationships during chronic administration of GHRP-2 to humans
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This human study administered chronic GHRP-2, GHRH, or GHRP-2 + GHRH for 7-30 days to normal younger and older men and women to examine interrelationships between GHRP-2, GHRH and SRIF. The abstract reports that chronic administration of either GHRP-2 or GHRH could convert an additive GHRP-2 + GHRH GH response into a synergistic one, and that the type of synergistic response differed between chronic GHRP-2 and GHRH. Whether the GH response became desensitized during chronic administration was described as depending in part on dosage and frequency. The authors note the approach can be used to study in vivo actions of GHRP in GH regulation.
Abstract
Studies with chronic GHRP-2 or GHRH administration were performed to demonstrate and better understand the interrelationships between GHRP-2, GHRH and SRIF. Normal younger and older men and women received chronic GHRP-2, GHRH or GHRP-2 + GHRH for 7-30 days. It was demonstrated that chronic administration of either GHRP-2 or GHRH could convert an additive GHRP-2 + GHRH GH response to a synergistic one. In addition, the type of synergistic response induced by chronic GHRP-2 versus GHRH was different. Whether the GH response becomes desensitized during chronic administration depends in part on the dosage and frequency of administration. The potential to learn more about the in vivo actions of GHRP relative to the regulation of GH secretion is underscored by studying the GH responses to GHRP-2, GHRH and GHRP-2 + GHRH.
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