Study summary · research use only
[Effect of thymalin on blood coagulation and fibrinolysis]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study in 20 cats examined effects of intravenous thrombin on blood coagulation and fibrinolysis. Within the first minutes after thrombin administration, blood coagulation was enhanced, fibrinogen concentration abruptly lowered, antithrombin III activity increased, and fibrinolysis inhibited; 30-60 minutes later a secondary hypocoagulation developed, accompanied by increased natural anticoagulant levels and marked enhancement of fibrinolytic activity. In animals given timalin at a dose of 2 mg for 5 days, thrombin injection was associated with a more pronounced increase in blood fibrinolytic activity compared to animals not given timalin.
Abstract
Experiments were made on 20 cats to show that within the first minutes intravenous administration of thrombin led to the enhancement of blood coagulation, an abrupt lowering in fibrinogen concentration, growth of antithrombin III activity and inhibition of fibrinolysis. 30-60 minutes after thrombin injection there developed a secondary hypocoagulation accompanied by the increment of the level of natural anticoagulants and by drastic enhancement of fibrinolysis. In animals given timalin in a dose of 2 mg for 5 days, the injection of thrombin produced a more remarkable increase in blood fibrinolytic activity.
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