Study summary · research use only
Significance of the LL-37 Peptide Delivered from Human Cathelicidin in the Pathogenesis, Treatment, and Diagnosis of Sepsis
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses the human LL-37 peptide, derived from cathelicidin antibacterial protein (h-CAP18), in relation to sepsis pathogenesis, treatment, and diagnosis. It notes that blood LL-37 concentrations change with high dynamics during sepsis, and that in animal models, administering exogenous LL-37 to mice with experimentally induced sepsis increased survival. The authors state that treatment of sepsis remains complex, and suggest that understanding LL-37's molecular mechanism, along with synthesizing stable analogs, could contribute to progress in sepsis diagnosis and therapy.
Abstract
Antimicrobial peptides, which function as the first line of host immune defense, have recently been identified as important immunomodulators of inflammation, and are involved as regulatory molecules in infections, including sepsis. Treatment of sepsis is very complex and remains largely challenging and sometimes ineffective. This creates a need to develop new therapeutic strategies focusing not only on the elimination of sepsis-causing microorganisms, which can be achieved with antibiotics, but also on the control of the immune system and its overactive response resulting in increased vascular endothelial permeability. One approach to develop new treatments for patients with sepsis is to better understand the pleiotropic function of the human LL-37 peptide that originates from the human cathelicidin antibacterial protein (h-CAP18). An increasing number of studies indicate high dynamics of changes in LL-37 concentration in the blood during sepsis. Additionally, in animal models, administration of exogenous LL-37 peptide to mice with experimentally induced sepsis increases their survival. It can therefore be assumed that knowledge of the molecular mechanism of cathelicidin LL-37 action, as well as the synthesis of its stable analogs, will result in progress in the diagnosis and therapy of sepsis.
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