Study summary · research use only
An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study (species not specified for the in vivo inflammation model) developed an injectable filler combining glycyl-L-histidyl-L-lysine copper complex (GHK-Cu) adsorbed onto hydroxyapatite microspheres (HAPs), mixed with carboxymethyl cellulose, glycerol, and water to form a GHK-Cu@CMHA gel. The abstract reports GHK-Cu was loaded by electrostatic adsorption, that the gel showed sustained release over 7 days with good flowability and injectability, and that in LPS-induced inflammation models in vivo and in vitro, GHK-Cu@CMHA was associated with reduced inflammatory factor and reactive oxygen species levels and increased superoxide dismutase activity. H&E and Masson staining showed collagen deposition.
Abstract
With the wide application of soft tissue fillers, implant material-induced inflammatory reactions have become a key factor affecting the therapeutic efficacy. This study developed an injectable filler with enhanced anti-inflammatory and antioxidant effects by adsorbing glycyl-L-histidyl-L-lysine copper complex (GHK-Cu) onto hydroxyapatite microspheres (HAPs), marking the first combination of HAPs and GHK-Cu to address inflammation caused by soft tissue fillers. GHK-Cu was successfully loaded onto HAPs by electrostatic adsorption. HAPs were then mixed with carboxymethyl cellulose (CMC), glycerol (GLY), and water to form GHK-Cu@CMHA gel. The study focus on the effective combination of HAPs as a carrier for sustained GHK-Cu delivery and the anti-inflammatory properties of GHK-Cu. GHK-Cu@CMHA exhibits sustained release properties for 7 days, which ensures prolonged therapeutic effects, minimizes peptide waste and reduces injection frequency, with good flowability and injectability. In the model of LPS-induced inflammation model in vivo and in vitro, GHK-Cu@CMHA gel reduced levels of inflammatory factors and Reactive oxygen species (ROS) levels decreased, while superoxide dismutase (SOD) activity was enhanced. In this process, H&E staining and Masson staining revealed significant collagen deposition. These findings further confirm that GHK-Cu@CMHA is a novel injectable soft tissue filler with good anti-inflammatory and antioxidant properties, which holds well potential for inflammation inhibition.
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