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Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics

Study · human · International journal of toxicology · 2025 · DOI 10.1177/10915818251340391 · PMID 40673537

Plain-language summary

Paraphrased from the published abstract below — not a verdict on whether anything works.

This is a cosmetic ingredient review by an expert panel, evaluating Acetyl Hexapeptide-8 Amide (synonymous with Acetyl Hexapeptide-8), an ingredient reported to function as a skin conditioning agent in cosmetics. The panel reviewed data relevant to its use in cosmetic formulations and, for present practices of use at concentrations up to 0.005%, reported no concerns preventing continued use. The panel further reported that available data were insufficient to make a determination for concentrations greater than 0.005%.

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Acetyl Hexapeptide-8 Amide (synonymous with Acetyl Hexapeptide-8 (sans "Amide")) in cosmetic products; this ingredient is reported to function as a skin conditioning agent - miscellaneous in cosmetics. The Panel reviewed data relevant to the safety of this ingredient in cosmetic formulations, and concluded that Acetyl Hexapeptide-8 Amide is safe in cosmetics in the present practices of use at concentrations up to 0.005%. The Panel further concluded that the available data are insufficient to make a determination that Acetyl Hexapeptide-8 Amide is safe under the intended conditions of use in cosmetic formulations at concentrations greater than 0.005%.

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