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Novel Pharmacologic Treatments of Female Sexual Dysfunction

Review · human · Clinical obstetrics and gynecology · 2025 · DOI 10.1097/GRF.0000000000000922 · PMID 39846877

Plain-language summary

Paraphrased from the published abstract below — not a verdict on whether anything works.

This review discusses pharmacologic treatments for female sexual dysfunction in humans, focusing on hypoactive sexual desire disorder. It covers FDA-approved medications (flibanserin and bremelanotide) and investigational therapies (Lorexys and testosterone combinations), describing study outcomes, safety profiles, and clinical strategies for diagnosis, patient selection, expectation setting, side effect management, and patient education. No specific numeric trial results are given in the abstract.

Abstract

This review evaluates pharmacologic treatments for female sexual dysfunction (FSD), focusing on hypoactive sexual desire disorder (HSDD). We provide clinically relevant applications for Food and Drug Administration (FDA)-approved medications (flibanserin and bremelanotide) and investigational therapies (Lorexys and testosterone combinations). Detailed study outcomes, safety profiles, and clinical strategies guide clinicians in appropriate diagnosis, patient selection, expectation setting, side effect management, and patient education, improving treatment outcomes and patient satisfaction.

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