Study summary · research use only
[Cognitive impairment in post-traumatic stress disorder]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review (abstract given in English and Russian; summarized from the English portion) discusses cognitive impairment in humans with post-traumatic stress disorder (PTSD), a condition reported to occur in up to 12.5% of primary care patients and most often described in combat veterans and victims of terrorist attacks, though it can also follow traumatic brain injury or medical interventions. The authors describe impaired attention, processing speed, executive function, and verbal learning and memory in PTSD, noting persistence similar to neuropsychological impairment in neurodegenerative disease. Possible pathogenetic mechanisms discussed include neuroinflammation, oxidative stress, and reduced neurotrophic factor production. The review names Cerebrolysin, described as having neurotrophic and anti-inflammatory activity, as one area of treatment interest.
Abstract
Post-traumatic stress disorder (PTSD) is a common mental health disorder, with an incidence of up to 12.5% among primary care patients. Most often, PTSD is detected in combat veterans, victims of terrorist attacks and terror, but it can also be a consequence of traumatic brain injury and medical interventions. Impaired cognitive functioning is a key feature of PTSD, including attention deficits and reduced processing speed, executive dysfunction, and impairments in verbal learning and memory. Cognitive impairments in PTSD are significantly persistent and are largely similar in nature to neuropsychological impairments in neurodegenerative pathology. Possible pathogenetic mechanisms underlying PTSD are the development of neuroinflammation, oxidative stress and decreased production of neurotrophic factors. One of the promising areas of treatment is the use of Cerebrolysin, which has powerful neurotrophic and anti-inflammatory activity. Посттравматическое стрессовое расстройство (ПТСР) является распространенной психической патологией, частота которой среди пациентов первичной медико-санитарной помощи достигает 12,5%. Наиболее часто ПТСР выявляется у ветеранов боевых действий, жертв терактов, однако также может быть следствием черепно-мозговой травмы, медицинских вмешательств. Нарушение когнитивных функций является ключевой особенностью ПТСР, включающей дефицит внимания и снижение скорости обработки информации, исполнительную дисфункцию, а также нарушение вербального обучения и памяти. Когнитивные нарушения при ПТСР отличаются значительной стойкостью и по своему характеру во многом схожи с нейропсихологическими нарушениями при нейродегенеративной патологии. Возможными патогенетическими механизмами, лежащими в основе ПТСР, являются развитие нейровоспаления, оксидантный стресс и снижение выработки нейротрофических факторов. Одно из перспективных направлений лечения — применение Церебролизина, обладающего мощной нейротрофической и противовоспалительной активностью.
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