Study summary · research use only
Neuroprotective Action of Humanin and Humanin Analogues: Research Findings and Perspectives
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review article (species not specified; no single experimental subject group) discusses humanin, a 24-mer peptide first described in the early 2000s as a neuroprotective/cytoprotective factor that rescues neuronal cells from death linked to Alzheimer's disease-associated insults. The authors describe humanin as a mitochondrial-derived peptide with reported cytoprotective effects in in vitro and in vivo models of various diseases, including neurodegenerative disorders, age-related macular degeneration, cardiovascular disease, and diabetes mellitus. The review focuses on recent in vitro and in vivo findings regarding the neuroprotective actions of humanin and its synthetic analogues, and the mechanisms proposed to underlie these actions, and discusses prospects for future research into humanin and its analogues for neurodegenerative and neural diseases.
Abstract
Humanin is a 24-mer peptide first reported in the early 2000s as a new neuroprotective/cytoprotective factor rescuing neuronal cells from death induced by various Alzheimer's disease-associated insults. Nowadays it is known that humanin belongs to the novel class of the so-called mitochondrial-derived peptides (which are encoded by mitochondrial DNA) and has been shown to exert beneficial cytoprotective effects in a series of in vitro and/or in vivo experimental models of human diseases, including not only neurodegenerative disorders but other human diseases as well (e.g., age-related macular degeneration, cardiovascular diseases, or diabetes mellitus). This review article is focused on the presentation of recent in vitro and in vivo research results associated with the neuroprotective action of humanin as well as of various, mainly synthetic, analogues of the peptide; moreover, the main mode(s)/mechanism(s) through which humanin and humanin analogues may exert in vitro and in vivo regarding neuroprotection have been reported. The prospects of humanin and humanin analogues to be further investigated in the frame of future research endeavors against neurodegenerative/neural diseases have also been briefly discussed.
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