Study summary · research use only
Use of the Subcutaneous Triptorelin Stimulation Test for Diagnosis of Central Precocious Puberty
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This retrospective human study evaluated a subcutaneous triptorelin stimulation test as an alternative to the intravenous gonadorelin test for diagnosing central precocious puberty (CPP) in girls. Medical records of 220 girls who underwent either test were reviewed, comparing 111 girls with CPP and 109 with idiopathic premature thelarche using the gonadorelin, triptorelin 120 min, and triptorelin 180 min tests. The CPP group had higher basal and peak gonadotropin levels, more advanced bone age, and a lower BMI standard deviation score. In the gonadorelin group, CPP girls peaked 30-60 min after injection; in the triptorelin group, most CPP girls (n = 68) peaked 60-180 min after injection. A peak LH concentration of ≥ 4.52 IU/L at 120 min gave the highest diagnostic accuracy, with sensitivity and specificity of 100% and 95.83%.
Abstract
The gold standard gonadotropin-releasing hormone (GnRH) stimulation test uses the response to intravenously injected gonadorelin to diagnose central precocious puberty (CPP). However, gonadorelin is not always readily available. This study investigated the diagnostic efficacy of the subcutaneous triptorelin test and the optimal blood sampling time for diagnosis of CPP. This study retrospectively examined the medical records of 220 girls who had undergone either the triptorelin or gonadorelin test and compared their clinical characteristics. We retrospectively compared clinical parameters between girls diagnosed with CPP (n = 111) and idiopathic premature thelarche (IPT) (n = 109) using three different diagnostic methods: the gonadorelin, triptorelin 120 min, and triptorelin 180 min tests. The diagnostic ability of the stimulated luteinizing hormone (LH) concentration in the triptorelin test for CPP was evaluated using receiver operating characteristic (ROC) analysis. The CPP group exhibited higher basal and peak gonadotropin levels, more advanced bone age, and a lower body mass index standard deviation score than the IPT group. In the gonadorelin test group, all girls with CPP exhibited a peak LH response 30-60 min after intravenous gonadorelin injection. In the triptorelin test group, most girls with CPP exhibited a peak LH response 60-180 min after subcutaneous triptorelin injection (n = 68). On the ROC curve, a peak LH concentration of ≥ 4.52 IU/L at 120 min had the highest CPP diagnostic accuracy, with sensitivity and specificity of 100% and 95.83%, respectively.
pepmg summarizes the peer-reviewed literature and links to every source — it sells nothing, ships nothing, and gives no medical, dosing, or human-use guidance. Don't just trust this summary: follow the citation to its source and read it yourself. Research use only.