Study summary · research use only
Nanowired delivery of antibodies to tau and neuronal nitric oxide synthase together with cerebrolysin attenuates traumatic brain injury induced exacerbation of brain pathology in Parkinson's disease
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study (species not specified) examined nanowired delivery of monoclonal antibodies against neuronal nitric oxide synthase (nNOS) and phosphorylated tau (p-tau), combined with cerebrolysin, a mixture of neurotrophic factors and peptide fragments, in a model of traumatic brain injury (concussive head injury) that exacerbates Parkinson's disease (PD) brain pathology. The authors describe PD and concussive head injury as involving oxidative stress and disrupted neurotrophic factor regulation associated with p-tau deposition, and hypothesized that nanodelivery of agents balancing neurotrophic factors and reducing oxidative stress could offer neuroprotection. Combined administration of nanowired anti-nNOS and anti-p-tau antibodies with cerebrolysin was reported to reduce concussive head injury-induced worsening of PD brain pathology, with this combination also showing benefits in concussive head injury or PD alone that had not been previously reported.
Abstract
Concussive head injury (CHI) is one of the major risk factors for developing Parkinson's disease in later life of military personnel affecting lifetime functional and cognitive disturbances. Till date no suitable therapies are available to attenuate CHI or PD induced brain pathology. Thus, further exploration of novel therapeutic agents are highly warranted using nanomedicine in enhancing the quality of life of veterans or service members of US military. Since PD or CHI induces oxidative stress and perturbs neurotrophic factors regulation associated with phosphorylated tau (p-tau) deposition, a possibility exists that nanodelivery of agents that could enhance neurotrophic factors balance and attenuate oxidative stress could be neuroprotective in nature. In this review, nanowired delivery of cerebrolysin-a balanced composition of several neurotrophic factors and active peptide fragments together with monoclonal antibodies to neuronal nitric oxide synthase (nNOS) with p-tau antibodies was examined in PD following CHI in model experiments. Our results suggest that combined administration of nanowired antibodies to nNOS and p-tau together with cerebrolysin significantly attenuated CHI induced exacerbation of PD brain pathology. This combined treatment also has beneficial effects in CHI or PD alone, not reported earlier.
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