Study summary · research use only
The role of vasoactive intestinal peptide in pulmonary diseases
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review article discusses vasoactive intestinal peptide (VIP), an abundant lung and systemic neurotransmitter, first discovered in 1970, and its relevance to pulmonary disease. The authors describe renewed interest in VIP due to potential application in COVID-19 following an earlier wave of research in the 1980s and 1990s, and outline its described biological roles beyond COVID-19, including in pulmonary arterial hypertension, chronic obstructive pulmonary disease, asthma, cystic fibrosis, acute lung injury/acute respiratory distress syndrome, pulmonary fibrosis, and lung tumors. Species and study type are not specified, as this is a literature review. The review also describes two main limitations of VIP as a potential medication and summarizes information on extended-release formulations and VIP analogues.
Abstract
Vasoactive intestinal peptide (VIP) is an abundant neurotransmitter in the lungs and other organs. Its discovery dates back to 1970. And VIP gains attention again due to the potential application in COVID-19 after a research wave in the 1980s and 1990s. The diverse biological impacts of VIP extend beyond its usage in COVID-19 treatment, encompassing its involvement in various pulmonary and systemic disorders. This review centers on the function of VIP in various lung diseases, such as pulmonary arterial hypertension, chronic obstructive pulmonary disease, asthma, cystic fibrosis, acute lung injury/acute respiratory distress syndrome, pulmonary fibrosis, and lung tumors. This review also outlines two main limitations of VIP as a potential medication and gathers information on extended-release formulations and VIP analogues.
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