Study summary · research use only
EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE "OLD" CHROMATIN
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study examined chromatin in lymphocyte cultures from human individuals aged 75-88 years, using molecular-cytogenetic methods including differential scanning calorimetry, ribosomal gene (NOR) activity, C-heterochromatin polymorphism, and sister chromatid exchange (SCE) analysis. The authors report progressive chromosome heterochromatinization with aging and describe treatment with peptide bioregulators (Ala-Glu-Asp-Gly-Epitalon, Lys-Glu-Asp-Ala-Livagen, Ala-Glu-Asp-Pro-Cortagen, and Lys-Glu-Vilon) as inducing deheterochromatinization (decondensation) of total heterochromatin and satellite stalks of acrocentric chromosomes and activating ribosomal gene synthetic processes, without deheterochromatinizing pericentromeric structural heterochromatin. The authors state that each peptide bioregulator showed a selective effect on particular chromosome regions in this study.
Abstract
In the present study, on the one hand, the epigenetic modification of condensed "old" chromatin was determined, and on the other hand, the influence of peptide bioregulators (Ala-Glu-Asp-Gly-Epitalon; Lys-Glu-Asp-Ala-Livagen; Ala-Glu-Asp-Pro - Cortagen and Lys-Glu - Vilon) on condensed chromatin in lymphocytes from old individuals. Were used molecular-cytogenetic methods: differential scanning calorimetry; activity of ribosomal genes of acrocentric chromosome satellite stalks-NORs; polymorphism of structural pericentromeric C-heterochromatin; variability of the facultative heterochromatin (sister chromatid exchanges - SCE) in the culture of lymphocytes from 75-88-year-old individuals. The analysis of results shows the chromosome progressive heterochromatinization (condensation of eu - and heterochromatin regions) occur in aging. Epigenetics process - heterochromatinization can deactivate many previously functioning active genes. It blocks certain stages of normal metabolic processes in the cell, which inhibits many specific enzymes and leads to aging pathologies. We show that peptide bioregulators induced unrolling deheterochromatinization (decondensation) of total heterochromatin, deheterochromatinization of satellite stalks of acrocentric chromosome, activating synthetic processes of ribosomal genes, does not cause deheterochromatinized of pericentromeric structural heterochromatin. This data also indicates that each of the studied peptide bioregulators (Ala-Glu-Asp-Gly; Lys-Glu-Asp-Ala; Ala-Glu-Asp-Pro and Lys-Glu) has a selective effect on definite regions of chromosomes. Thus, short peptide bioregulators induce selective heterochromatinization and deheterochromatinization of chromosome regions (remodeling of facultative heterochromatin) in individuals 75-88 years old that opens up new opportunities in the treatment of aging diseases.
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