Study summary · research use only
Cerebrolysin in Patients with TBI: Systematic Review and Meta-Analysis
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This systematic review and meta-analysis (human TBI patients) searched PubMed, Cinahl, Web of Science, and Embase from database inception until 11th July 2022 for clinical studies of cerebrolysin, a mixture of neuropeptides derived from purified porcine brain proteins, in traumatic brain injury (TBI). Ten clinical studies, including both retrospective and prospective designs covering 8749 patients, were included in the final analysis. Cerebrolysin treatment was associated with a statistically significant change in Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) scores, while mortality of any cause and length of hospital stay were not affected. The authors describe these findings as supporting further multi-center studies to optimize dosing and timing of cerebrolysin administration after TBI.
Abstract
TBI (traumatic brain injury) is one of the most common causes of deaths and failure to return to society according to the latest statistics. Cerebrolysin is a drug approved for use in patients diagnosed with TBI. It is a mixture of neuropeptides derived from purified porcine brain proteins and multiple experimental studies have proven its neuroprotective and neurorestorative properties both in vitro and in vivo. In our meta-analysis, we analyze the latest clinical study reports on the use of Cerebrolysin in patients with TBI. The authors searched the databases: Pub Med, Cinahl, Web Of Science, and Embase from database inception until 11th July 2022. Ten clinical studies were eligible and included in the final analysis, including both retrospective and prospective studies of 8749 patients. Treatment with Cerebrolysin was associated with a statistically significant change in GCS and GOS. Mortality of any cause and the length of stay was not affected by the treatment. Our findings support and confirm the beneficial effects of Cerebrolysin treatment on the clinical outcome of patients after TBI. Further multi-center studies to optimize dosing and time of administration should be conducted.
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