Study summary · research use only
Advances and perspectives in the analytical technology for small peptide hormones analysis: A glimpse to gonadorelin
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses advances in analytical technology for small peptide hormones, using gonadorelin as a case example, tracing evolution from conventional lab-bench instrumentation toward simpler, on-site techniques with reduced analysis time and cost. The authors describe development of affinity reagents from natural receptors toward biomimetic, animal-free abiotic receptors such as aptamers and molecular imprinted polymers (MIPs), and summarize chromatography-, immunochemistry-, and affinity sensing-based approaches to peptide hormone analysis. The review presents gonadorelin, a neuropeptide, as a therapeutic drug that has drawn attention due to misuse in doping practices during sports competitions, describing peptide hormone analysis as a current challenge for biomedical, pharmaceutical, and anti-doping analysis.
Abstract
In the last twenty years, we have witnessed an important evolution of bioanalytical approaches moving from conventional lab bench instrumentation to simpler, easy-to-use techniques to deliver analytical responses on-site, with reduced analysis times and costs. In this frame, affinity reagents production has also jointly advanced from natural receptors to biomimetic, abiotic receptors, animal-free produced. Among biomimetic ones, aptamers, and molecular imprinted polymers (MIPs) play a leading role. Herein, our motivation is to provide insights into the evolution of conventional and innovative analytical approaches based on chromatography, immunochemistry, and affinity sensing referred to as peptide hormones. Indeed, the analysis of peptide hormones represents a current challenge for biomedical, pharmaceutical, and anti-doping analysis. Specifically, as a paradigmatic example, we report the case of gonadorelin, a neuropeptide that in recent years has drawn a lot of attention as a therapeutic drug misused in doping practices during sports competitions.
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