Study summary · research use only
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study using a naloxone-precipitated morphine withdrawal model, researchers tested Selank, a peptide analog of tuftsin, given as a single intraperitoneal injection at 0.3 mg/kg, compared with diazepam at 2 mg/kg and an active control group. Selank reduced the total index of morphine withdrawal syndrome by 39.6%, significantly (р<0.0001) attenuated convulsive reactions, ptosis, and posture disorders, and produced a 9-fold increase in tactile sensitivity threshold in morphine-dependent rats compared with active control, though it was slightly less potent than diazepam, which decreased the total index by 49.3% and produced a 13-fold increase in sensitivity threshold. The authors describe Selank, like diazepam, as attenuating the aversive signs of morphine withdrawal in rats with opiate dependence.
Abstract
Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model. Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine withdrawal syndrome by 39.6%, significantly (р<0.0001) attenuated convulsive reactions, ptosis, and posture disorders, and 9-fold increased the tactile sensitivity threshold in morphine-dependent rats in comparison with the group of active control; at the same time, Selank was slightly inferior to diazepam in a dose of 2 mg/kg by pharmacological activity (the decrease in total index of morphine withdrawal syndrome by 49.3% and 13-fold increase in sensitivity threshold). Thus, Selank, like diazepam, weakens the aversive signs of morphine withdrawal in rats with opiate dependence.
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