Study summary · research use only
The potential of GHK as an anti-aging peptide
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses GHK (glycyl-L-histidyl-L-lysine), a peptide naturally found in human serum, with levels reported to average 200 ng/ml at age 20 and decline to an average of 80 ng/ml by age 60. GHK has a high affinity for copper, forming the chelate GHK-Cu. The abstract describes anti-inflammatory and tissue remodeling properties for both GHK and GHK-Cu, with GHK-Cu shown in in vitro and in vivo studies to promote skin remodeling, wound healing, and regeneration, along with antioxidant and anti-inflammatory effects. Preliminary observations are described as suggesting GHK can partially reverse cognitive impairment in aging mice by acting on anti-inflammatory and epigenetic pathways, providing rationale for further preclinical and clinical study.
Abstract
GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide found in human serum with levels averaging 200 ng/ml at age 20 but declining to an average of 80 ng/ml by age 60. The molecule has a very high affinity for copper and forms the chelate GHK-Cu. The peptide as well as its Cu (II) chelate have anti-inflammatory and tissue remodeling properties. GHK-Cu has been shown to promote skin remodeling, wound healing and regeneration, and has prominent antioxidant and anti-inflammatory effects in in vitro and in vivo studies. In addition, preliminary observations suggest GHK can partially reverse cognitive impairment in aging mice by targeting anti-inflammatory and epigenetic pathways. The evidence as presented provides the rationale to further investigate this naturally occurring peptide in preclinical and clinical aging studies.
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