Study summary · research use only
[Immunocorrective therapy of the traumatic syndrome]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study, the combined application of thymalin and plaferon was investigated for prophylaxis and treatment of traumatic syndrome. Traumatic shock was induced by Kennon's method in male Wistar rats weighing 200-250 g, with post-traumatic syndrome observed over 7 days. Survival rate was used as the criterion of efficiency, alongside immunological protective factors. The combined treatment increased the survival rate twice within the first 7 days, per the abstract. The immunomodulating effect on day 7 was reported as most marked at the level of total T-lymphocyte population, theophylline-sensitive T suppressors, and blood serum lysozyme activity.
Abstract
The effect of combined application of thymalin and plaferon in the prophylaxis and treatment of traumatic syndrome has been investigated in rats. The survival rate was taken as the criterion of efficiency, the mechanism of the effect obtained being estimated at the level of immunological protective factors. Traumatic shock was induced by Kennon's method in Wistar male rats weighing 200-250 g. Post-traumatic syndrome has been observed within 7 days. The combined application of thymalin and plaferon has increased the survival rate twice within the first 7 days. Immunomodulating effect of the combined application of thymalin and plaferon on the 7th day of traumatic syndrome was most marked at the level of total T-lymphocyte population, theophylline-sensitive T suppressors and lysozyme blood serum activity.
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