Study summary · research use only
Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This double-blind, randomized, controlled, split-face human clinical trial evaluated a cross-linked hyaluronic acid (CLHA)-based microneedle patch containing acetyl hexapeptide-8 (AHP-8) or epidermal growth factor (EGF) for wrinkle improvement in 52 Korean female subjects. Subjects were divided into three groups: microneedle patch alone, microneedle patch with AHP-8, and microneedle patch with EGF, applied to the periorbital and nasolabial fold area once weekly for 29 days. Fifty subjects (96.2%) completed the study. On day 29, statistically significant improvements in wrinkle and skin hydration measures were observed in all groups, with the AHP-8 and EGF patches showing statistically significant improvements in wrinkle compared with the microneedle patch alone; no serious adverse effects were noted.
Abstract
Hyaluronic acid (HA)-based microneedle patch has recently been studied for wrinkle improvement. Cross-linked HA (CLHA) is widely used in dermal fillers. Acetyl hexapeptide-8 (AHP-8) and epidermal growth factor (EGF) are used for cosmetic ingredients. This study aimed to verify the efficacy of the CLHA/HA-based patch with microstructure (microneedle patch) containing AHP-8 or EGF. A total of 52 Korean females were enrolled in a double-blind, randomized, controlled, split-face trial. The subjects were divided into 3 groups: (1) microneedle patch alone, (2) microneedle patch/AHP-8, and (3) microneedle patch/EGF. The treatment was applied on the periorbital and nasolabial fold area for 4 hours to completely dissolve the microstructures once per week for 29 days. Evaluations, including photodamage scoring, image analysis with Antera 3D® (Miravex, Ireland), skin hydration measurement, and adverse effect assessments, were performed at each visit. Fifty subjects (96.2%) completed this clinical study. On day 29 after application, statistically significant improvements in wrinkle and skin hydration were observed in all groups (p<0.01). Treatment with microneedle patch/AHP-8 and microneedle patch/EGF showed statistically significant improvements in wrinkle compared with microneedle patch alone (p<0.05). No serious adverse effects were noted. Combination of CLHA-based microneedle patch and functional cosmetic ingredients can improve wrinkle with minimal discomfort.
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