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Oxytocin: A Potential Therapeutic for Obesity

Review · Journal of obesity & metabolic syndrome · 2021 · DOI 10.7570/jomes20098 · PMID 33820878

Plain-language summary

Paraphrased from the published abstract below — not a verdict on whether anything works.

This review article (species not specified) discusses oxytocin, a neuropeptide described as involved in regulating food consumption, energy homeostasis, and hedonic eating. The authors summarize studies in people with obesity or binge-eating that reported a hypophagic effect of oxytocin, with reduced caloric intake reported after administration. The authors describe multiple studies demonstrating effects of oxytocin on energy intake, food consumption, and weight, and discuss its potential therapeutic relevance for obesity and binge eating based on these reported effects on food intake and metabolism.

Abstract

Oxytocin is a neuropeptide involved in the homeostasis of food consumption and energy; it affects hedonic eating. Studies in obese or binge-eating patients reported the hypophagic effect of oxytocin, which reduced caloric intake after administration. Several studies have demonstrated the effect of oxytocin's increasing energy intake, decreasing food consumption, and contributing to weight loss. Oxytocin's effects on food intake and metabolism suggest its therapeutic potential for treating obesity and binge eating.

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