Study summary · research use only
SS-31 protect retinal pigment epithelial cells from H(2) O(2) -induced cell injury by reducing apoptosis
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This laboratory study used ARPE-19 cells, a human retinal pigment epithelial cell line, to examine the peptide d-Arg-2,6-dimethyltyrosine-Lys-Phe-NH2 (SS-31) in the context of hydrogen peroxide (H2O2)-induced cell injury. The authors report that SS-31 attenuated H2O2-induced loss of cell viability and reduced oxidative damage and apoptosis, with increased HO-1, Trx-1, and Nrf-2 expression compared with the H2O2 group. SS-31 was associated with downregulation of Bax and upregulation of Bcl-2. The authors describe SS-31 as having a protective effect against H2O2 exposure in these cells via enhanced antioxidative enzyme expression and decreased apoptosis, and suggest it could be considered for further investigation in retinal degeneration.
Abstract
Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells. Antioxidant supplementation is a plausible strategy to avoid oxidative stress and maintain the function of retina. d-Arg-2,6-dimethyltyrosine-Lys-Phe-NH2 (SS-31) has been used in the treatment of many diseases. In this study, we found that SS-31 attenuated hydrogen peroxide (H2 O2 )-induced loss of cell viability, reduced oxidative damage and cell apoptosis in RPE cells. HO-1, Trx-1 and Nrf-2 expression levels significantly increased on pre-treatment with SS-31 compared with the H2 O2 group. SS-31 inhibited apoptosis through the downregulation of Bax and the upregulation of Bcl-2. Our results suggest that SS-31 had a protective effect against H2 O2 treatment in ARPE-19 cells by enhancing the antioxidative enzymes expression and decreasing apoptosis, which could be considered a promising therapeutic intervention for retinal degeneration.
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