Study summary · research use only
Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study reports on a standard and complex treatment method using the peptide drug thymalin in patients with COVID-19 (human). The authors describe one mechanism of thymalin's immunomodulatory effect as its influence on the differentiation of human hematopoietic stem cells (HSCs). They report that, with standard treatment, control-group patients showed a decrease in the pro-inflammatory cytokine IL-6, C-reactive protein, and D-dimer, and that adding thymalin to standard therapy accelerated the decline in these indicators as well as in T cell system indicators, which the authors state helped reduce the risk of blood clots in COVID-19 patients. The authors describe these findings as a rationale for including thymalin in complex treatment of coronavirus infection.
Abstract
The paper presents the results of a standard and complex treatment method using the peptide drug thymus thymalin in patients with COVID-19. One of the mechanisms of the immunomodulatory effect of thymalin is considered to be the ability of this peptide drug to influence the differentiation of human hematopoietic stem cells (HSCs). It was found that, as a result of standard treatment, patients in the control group showed a decrease in the concentration of the pro-inflammatory cytokine IL-6, C-reactive protein, D-dimer. The addition of thymalin to standard therapy accelerated the decline in both these indicators and the indicators of the T cell system. This has helped reduce the risk of blood clots in COVID-19 patients. The revealed properties of the thymus peptide preparation are the rationale for its inclusion in the complex treatment of coronavirus infection. Peptideswith potential biological activity against SARS-CoV-2 virus [29]. Note: Nitrogen atoms are shown in blue, oxygen atoms - in red, carbon atoms - in gray, hydrogen atoms - in white, and phosphorus atoms - in yellow.
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