Study summary · research use only
A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto-perception
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This open-label human trial enrolled women aged 40 years and older with visible photoaging who applied a serum containing 15% l-ascorbic acid, tocopheryl acetate, and 5 ppm palmitoyl tripeptide-38 to the face once daily for 56 days, with skin roughness and isotropy assessed on days 0, 28, and 56, and self-assessment questionnaires completed every third day. The abstract reports that skin-roughness parameters decreased by 8%-9%, skin isotropy increased, redness decreased by 9%, and homogeneity increased by 8%, alongside participants' self-reported improvements in radiance, complexion, and wrinkles. The authors describe a statistically significant correlation between the objectively measured and self-perceived changes.
Abstract
Allegations on the benefits of incorporating vitamin C, vitamin E, and combinations thereof in topical skincare formulations are mostly based on in vitro and ex vivo experiments and/or limited protocols of specific stress conditions (pollution, UV exposure, laser irradiation,…). To evaluate the instrumentally measurable effects and quantitative consumer perceptions of a protective and reparative serum on a panel of volunteers under normal nonstressed conditions of use, employing FOITS technology and innovative self-assessment methods. In an open-label study women of ≥40 years with visible signs of photoaging applied a serum comprising l-ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide-38 to the face once daily for 56 days. Skin roughness and isotropy changes were evaluated on days 0, 28, and 56, visual instrumental evaluation of skin-tone parameters was assessed on days 0 and 56. Subjects completed self-assessment questionnaires every third day of the trial period for radiance, homogeneity, and wrinkle appearance. Skin-roughness parameters decreased significantly by 8%-9% (P < .05) and subjects experienced a significant increase in skin isotropy (P < .05). Photographic analysis revealed significant improvements in skin tone, with a 9% decrease in redness and 8% increase in homogeneity (P < .0001 for both), in excellent agreement with subjects' perception of significant improvements of radiance, complexion, and wrinkles. The study confirms statistically significant correlation between objectively measured and quantitative subjectively perceived benefits of the bespoke serum containing antioxidants and a matrix-restoring peptide.
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