Study summary · research use only
[The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology.]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review (species not specified, covering animal and in vitro models) describes hepatoprotective, immunoprotective, and antiageing properties reported for a liver polypeptide complex (Ventvil) and the tetrapeptide KEDA (Lys-Glu-Asp-Ala, Livagen). In experimental models of liver pathology (fibroid induration, acute and chronic hepatitis) and in vitro, the authors report that Ventvil and KEDA peptide were associated with normalized immune and antioxidant status and restored liver function during hepatitis, with the largest hepato- and immunoprotective effects noted in aging.
Abstract
The applying of many drugs in elderly and old people often is the reason of liver dysfunction. Thereat, the risk of liver fibroid induration, acute and chronic hepatitis increases during aging. It is the reason to find new, effective and harmless hepatoprotectors. In the review is shown the data of hepatoprotective, immunoprotective and antiageing properties of liver polypeptide complex (Ventvil) and KEDA tetrapeptide (Lys-Glu-Asp-Ala, Livagen). In liver pathology experimental models (liver fibroid induration, acute and chronic hepatitis) in amimals and in vitro was shown high efficiency of Ventvil and KEDA peptide. Ventvil and KEDA peptide had concordant effects - normalized immune and antioxidant status, restored liver function during hepatitis. It was demonstrated, that maximal hepato- and immunoprotective effect of peptides verified in aging. Применение большого числа лекарственных средств у лиц пожилого и старческого возраста часто приводит к нарушению функции печени. При этом с возрастом повышается риск развития цирроза печени, острого и хронического гепатита, что обусловливает необходимость поиска эффективных и безопасных гепатопротекторов. В обзоре приведены данные исследования гепатопротекторных, иммуномодулирующих и геропротекторных свойств полипептидного комплекса, экстрагированного из печени телят (Вентвил®) и тетрапептида KEDA (Lys-Glu-Asp-Ala, Ливаген). В моделях экспериментальной патологии печени у животных (острый и хронический гепатит, цирроз) и исследованиях in vitro показана высокая эффективность Вентвила и пептида KEDA. Вентвил и пептид KEDA обладают сходными свойствами — приводят к норме иммунный и антиоксидантный статус, восстанавливают функции печени при гепатите. Показано, что наибольшее гепато- и иммунопротекторное действие пептидов проявляется при старении.
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