Study summary · research use only
NAD(+) Repletion Rescues Female Fertility during Reproductive Aging
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study (species not specified, describing female mammals) examined reproductive aging and oocyte quality relative to levels of nicotinamide adenine dinucleotide (NAD+). The authors report that treatment with the NAD+ precursor nicotinamide mononucleotide (NMN) was associated with restored oocyte quality and fertility in aged animals, an effect also produced by transgenic overexpression of the NAD+-dependent deacylase SIRT2, while deletion of this enzyme did not impair oocyte quality. Supplementation was reported to reverse the adverse effect of maternal age on developmental milestones in the embryo. The authors suggest that late-life restoration of NAD+ levels may represent an opportunity to affect female reproductive function in mammals.
Abstract
Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinucleotide (NAD+). Treatment with the NAD+ metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD+-dependent deacylase SIRT2, though deletion of this enzyme does not impair oocyte quality. These benefits of NMN extend to the developing embryo, where supplementation reverses the adverse effect of maternal age on developmental milestones. These findings suggest that late-life restoration of NAD+ levels represents an opportunity to rescue female reproductive function in mammals.
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