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Cathelicidin LL-37 (an antimicrobial peptide)-induced colistin dependence in Acinetobacter baumannii
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This in vitro bacterial study (species not specified for a host organism, using Acinetobacter baumannii isolates) examined development of colistin dependence after exposure to the human antimicrobial peptide LL-37. The authors report that LL-37-induced colistin-dependent mutants showed susceptibility to several other antibiotics and carried IS1595 or ATTT insertions in LpxACD.
Abstract
In this study, we demonstrated the development of colistin dependence in Acinetobacter baumannii isolates after exposure to the human cationic antimicrobial peptide LL-37. The LL-37-induced colistin-dependent mutants showed susceptibility to many other antibiotics and IS1595 or ATTT insertions in LpxACD.
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