Study summary · research use only
KISS1 in breast cancer progression and autophagy
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This is a review discussing KISS1, a precursor to peptides including metastin (Kisspeptin-54), Kisspeptin-14, Kisspeptin-13, and Kisspeptin-10, in the context of breast cancer progression and autophagy (species not specified; no original experimental data presented). The abstract describes KISS1 as a metastasis suppressor protein whose expression is commonly downregulated in metastatic tumors of various origins, discusses its proposed role in suppressing colonization of disseminated cancer cells, and notes evidence of KISS1 involvement in tumor angiogenesis, autophagy, and apoptosis regulation. The authors discuss KISS1 as a potential diagnostic marker and note it has been considered in anti-cancer therapeutics.
Abstract
Tumor suppressors are cellular proteins typically expressed in normal (non-cancer) cells that not only regulate such cellular functions as proliferation, migration and adhesion, but can also be secreted into extracellular space and serve as biomarkers for pathological conditions or tumor progression. KISS1, a precursor for several shorter peptides, known as metastin (Kisspeptin-54), Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10, is one of those metastasis suppressor proteins, whose expression is commonly downregulated in the metastatic tumors of various origins. The commonly accepted role of KISS1 in metastatic tumor progression mechanism is the ability of this protein to suppress colonization of disseminated cancer cells in distant organs critical for the formation of the secondary tumor foci. Besides, recent evidence suggests involvement of KISS1 in the mechanisms of tumor angiogenesis, autophagy and apoptosis regulation, suggesting a possible role in both restricting and promoting cancer cell invasion. Here, we discuss the role of KISS1 in regulating metastases, the link between KISS1 expression and the autophagy-related biology of cancer cells and the perspectives of using KISS1 as a potential diagnostic marker for cancer progression as well as a new anti-cancer therapeutics.
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