Study summary · research use only
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study, Selank, a peptide analogue of tuftsin, was administered (0.3 mg/kg a day, intraperitoneally, for 7 days) to outbred rats that received 10% ethanol as their only fluid source for 30 weeks. In the object recognition test, Selank was associated with a cognitive-stimulating effect in 9 months rats not exposed to ethanol and with prevention of ethanol-induced memory and attention disturbances during alcohol withdrawal. In ex vivo experiments, Selank was associated with prevention of an ethanol-induced increase in brain-derived neurotrophic factor (BDNF) content in the hippocampus and frontal cortex. The authors describe these findings as indicating effects of the tuftsin analogue on age-related memory disturbances linked to chronic alcohol intoxication, involving BDNF-related neurotrophin mechanisms.
Abstract
The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks. In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances (p<0.01) developing during alcohol withdrawal. In ex vivo experiments, Selank prevented ethanol-induced increase in BDNF content in the hippocampus and frontal cortex (p<0.05). These results indicate positive effects of the tuftsin analogue on age-related memory disturbances associated with chronic alcohol intoxication and confirm the involvement of the neurotrophin mechanism related to BDNF production into the effect of Selank.
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