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NAD(+) in Brain Aging and Neurodegenerative Disorders
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses the role of NAD+, a metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival, in brain aging and neurodegenerative disorders. The authors describe NAD+-dependent enzymes as involved in synaptic plasticity and neuronal stress resistance, and review findings on NAD+ and related metabolites in neuronal adaptation to physiological stressors and in processes occurring in Alzheimer's, Parkinson's, and Huntington diseases, and amyotrophic lateral sclerosis. They state that advances in understanding NAD+-based neuronal resilience could lead to new approaches for brain aging and neurological disorder treatment. Species not specified.
Abstract
NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer's, Parkinson's, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD+-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.
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