Study summary · research use only
Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses recent findings on vasoactive intestinal peptide (VIP), a gut peptide hormone first reported as a vasodilator in 1970, focusing on its role in the gastrointestinal system. The authors describe VIP's physiological and pathological effects on development, growth, and neuronal, epithelial, and endocrine cell functions that regulate ion secretion, nutrient absorption, gut motility, glycemic control, carcinogenesis, immune responses, and circadian rhythms. They note that genetic ablation of VIP and its receptors in mice has provided insights into VIP's role in physiological signaling and disease pathogenesis, and discuss possible therapeutic applications of VIP to diabetes, autoimmune diseases, and cancer.
Abstract
Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions that in turn regulate ion secretion, nutrient absorption, gut motility, glycemic control, carcinogenesis, immune responses, and circadian rhythms. Genetic ablation of this peptide and its receptors in mice also provides new insights into the contribution of VIP towards physiological signaling and the pathogenesis of related diseases. Here, we discuss the impact of VIP on gastrointestinal function and diseases based on recent findings, also providing insight into its possible therapeutic application to diabetes, autoimmune diseases and cancer.
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