Study summary · research use only
Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study in male Wistar rats, the authors examined effects of Selank on liver morphology during chronic foot-shock stress. Selank was injected intraperitoneally at doses of 100, 300 and 1000 μg/kg 15 min before each stress session. Chronic foot-shock stress was associated with hydropic degeneration of hepatocytes, an increased nucleus/cytoplasm ratio, focal necroses, and lymphohistiocyte infiltration. Selank at all doses reduced the intensity of these stress-induced changes, and doses of 300 and 1000 μg/kg restored the nucleus/cytoplasm ratio in hepatocytes. The authors report the largest stress-limiting effect was seen with the 300 μg/kg dose.
Abstract
We studied the effects of Selank on morphological parameters of the liver in Wistar male rats subjected to chronic foot-shock stress. Selank was injected intraperitoneally in doses of 100, 300 and 1000 μg/kg 15 min before each stress session. Morphological and morphometrical analysis showed that chronic foot-shock stress induced hydropic degeneration of hepatocytes, an increase of the nucleus/cytoplasm ratio due to an increase in the area of nuclei and reduction of the cytoplasm area, the appearance of focal necroses, and lymphohistiocyte infiltration. Injection of Selank in all doses reduced the intensity of stress-induced degenerative changes. Administration of Selank in doses of 300 and 1000 μg/kg restored the nucleus/cytoplasm ratio in hepatocytes. The maximum stress-limiting effect was attained after administration of 300 μg/kg Selank.
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