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State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study in male Wistar rats, the authors examined effects of Selank on intestinal microbiota during chronic restraint stress. Selank was injected intraperitoneally at doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress was associated with a decrease in obligate microflora content and an increase in opportunistic microorganisms. Selank was reported to restore intestinal microbiota, which the authors attribute to central (neurotropic) and peripheral (immunotropic) mechanisms.
Abstract
We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.
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