Study summary · research use only
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review (species not specified) discusses regenerative and protective actions of the human peptide GHK (glycyl-l-histidyl-l-lysine) in light of new gene data. The authors describe GHK as having multiple reported biological actions, including stimulation of blood vessel and nerve outgrowth, increased collagen, elastin, and glycosaminoglycan synthesis, and support of dermal fibroblast function, with reported tissue repair effects described for skin, lung connective tissue, boney tissue, liver, and stomach lining. The review also describes reported cell protective actions attributed to GHK, including anti-cancer and anti-inflammatory activities, lung protection and restoration of COPD fibroblasts, suppression of molecules described as potentially accelerating diseases of aging such as NF-κB, anti-anxiety, anti-pain, and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system, attributed to genetic data revealing multiple biochemical pathways.
Abstract
The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, anti-pain and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system. Recent genetic data may explain such diverse protective and healing actions of one molecule, revealing multiple biochemical pathways regulated by GHK.
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