Study summary · research use only
Regulation of cellular senescence via the FOXO4-p53 axis
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review (species not specified) discusses regulation of cellular senescence via the FOXO4-p53 axis. It describes FOXO (Forkhead box O) and p53 proteins as transcription factors that regulate cell cycle, apoptosis, and metabolism, and notes both have been identified as playing roles in aging, with their misregulation linked to numerous diseases including cancers. The authors focus on shared activities between FOXOs and p53, particularly their role in regulating cellular senescence, and discuss potential strategies for targeting the FOXO4-p53 interaction as a topic of interest for modulating cellular senescence in the study of aging-related diseases and morbidity.
Abstract
Forkhead box O (FOXO) and p53 proteins are transcription factors that regulate diverse signalling pathways to control cell cycle, apoptosis and metabolism. In the last decade both FOXO and p53 have been identified as key players in aging, and their misregulation is linked to numerous diseases including cancers. However, many of the underlying molecular mechanisms remain mysterious, including regulation of ageing by FOXOs and p53. Several activities appear to be shared between FOXOs and p53, including their central role in the regulation of cellular senescence. In this review, we will focus on the recent advances on the link between FOXOs and p53, with a particular focus on the FOXO4-p53 axis and the role of FOXO4/p53 in cellular senescence. Moreover, we discuss potential strategies for targeting the FOXO4-p53 interaction to modulate cellular senescence as a drug target in treatment of aging-related diseases and morbidity.
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