Study summary · research use only
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This is a review of in vivo evidence for NAD-boosting molecules. It describes nicotinamide adenine dinucleotide (NAD) as a redox cofactor that also functions as a signaling molecule, modulating NAD+-sensing enzymes that regulate processes from energy metabolism to cell survival, fluctuating with food intake, exercise, and time of day. The review states NAD+ levels decline with age, associated with altered metabolism and increased disease susceptibility, and reports that restoring NAD+ levels in old or diseased animals was associated with improved health measures and extended lifespan in the studies reviewed, prompting a search for NAD-boosting molecules intended to increase resilience and extend healthy human lifespan.
Abstract
Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is well known for its role in redox reactions. More recently, it has emerged as a signaling molecule. By modulating NAD+-sensing enzymes, NAD+ controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD+ levels steadily decline with age, resulting in altered metabolism and increased disease susceptibility. Restoration of NAD+ levels in old or diseased animals can promote health and extend lifespan, prompting a search for safe and efficacious NAD-boosting molecules that hold the promise of increasing the body's resilience, not just to one disease, but to many, thereby extending healthy human lifespan.
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