Study summary · research use only
NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This is a review discussing nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), two NAD+ intermediates studied for their role in age-associated functional decline and disease. The review describes supplementation of these NAD+ intermediates as having shown preventive and therapeutic effects in the studies reviewed, and notes that the pharmacokinetics and metabolic fates of NMN and NR are still under investigation, with fates appearing to depend on tissue distribution and expression of NAD+ biosynthetic enzymes, nucleotidases, and transporters. The authors describe a proposed concept connecting NAD+ metabolism to aging and longevity control in mammals.
Abstract
Research on the biology of NAD+ has been gaining momentum, providing many critical insights into the pathogenesis of age-associated functional decline and diseases. In particular, two key NAD+ intermediates, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), have been extensively studied over the past several years. Supplementing these NAD+ intermediates has shown preventive and therapeutic effects, ameliorating age-associated pathophysiologies and disease conditions. Although the pharmacokinetics and metabolic fates of NMN and NR are still under intensive investigation, these NAD+ intermediates can exhibit distinct behavior, and their fates appear to depend on the tissue distribution and expression levels of NAD+ biosynthetic enzymes, nucleotidases, and presumptive transporters for each. A comprehensive concept that connects NAD+ metabolism to the control of aging and longevity in mammals has been proposed, and the stage is now set to test whether these exciting preclinical results can be translated to improve human health.
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