Study summary · research use only
Local injection of d-lys-3-GHRP-6 in the rat amygdala, dentate gyrus or ventral tegmental area impairs memory consolidation
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study, adult male Wistar rats weighing 230-280g underwent stereotaxic surgery with cannulation of the amygdala, dentate gyrus, or ventral tegmental area, then received the GHS-R1a selective antagonist d-Lys-3-GHRP-6 (0.08, 0.8, and 8nM) or solvent immediately after training in a passive avoidance task; memory retrieval was assessed twenty four hours later. The abstract reports that post-training injection of d-Lys-3-GHRP-6 decreased step-through latency and increased entries into and time spent in the dark compartment, significantly and in a dose-dependent manner, across all three injection sites. The authors describe this as indicating that antagonism of GHS-R1a in these brain regions impairs memory consolidation.
Abstract
It is well known that the hormone ghrelin affects learning and memory in different experimental models of learning. Though, the effect of antagonism of ghrelin receptor type 1a (GHS-R1a) in various regions of the brain and on different stages of learning has not been examined. In this study the effect of injection of a GHS-R1a selective antagonist (d-Lys-3-GHRP-6) into the basolateral amygdala, dentate gyrus or ventral tegmental area was examined on memory consolidation in the passive avoidance task. Adult male Wistar rats weighing 230-280g were used. Animals underwent stereotaxic surgery and cannulated in their amygdala, dentate gyrus or ventral tegmental area. One week after surgery, the rats received different doses of d-Lys-3-GHRP-6 (0.08, 0.8, and 8nM), immediately after training. The control groups received solvent of the drug. Twenty four hours later in the test day, memory retrieval was assessed. In all groups, post-training injection of d-Lys-3-GHRP-6 decreased step-through latency and increased entries into the dark compartment and time spent in the dark compartment, significantly and in a dose-dependent manner. The results indicate that antagonism of the GHS-R1a in the rat amygdala, dentate gyrus or ventral tegmental area impairs memory consolidation and show that the ghrelin signaling has a widespread influence on cognitive performance.
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