Study summary · research use only
Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study in 28 human individuals aged 19-65 years (mean BMI 39.4 ± 9.4 kg/m2) examined growth hormone (GH) secretion and its response to the GH-releasing peptide (GHRP)-2-load test before and after laparoscopic sleeve gastrectomy (LSG) in obese patients. GH secretion peaks correlated negatively with BMI (r = -0.59, p = 0.001), visceral adipose tissue (r = -0.47, p = 0.005), and subcutaneous adipose tissue (r = -0.40, p = 0.04). In two obese patients, the response to the GHRP-2-load test changed markedly with weight loss 12 months after LSG. The authors report that GH secretion was decreased in obese patients in this study and changed following LSG.
Abstract
Because growth hormone (GH) secretion is reportedly decreased in obese patients, we examined not only the factors associated with the decreased GH secretion but also GH response to the GH-releasing peptide (GHRP)-2-load test before and after laparoscopic gastrectomy (LSG). The study comprised 28 individuals aged 19-65 years [mean body mass index (BMI), 39.4 ± 9.4 kg/m2]. In the univariate analysis, GH secretion peaks correlated negatively with BMI (r = -0.59, p = 0.001), visceral adipose tissue (r = -0.47, p = 0.005), and subcutaneous adipose tissue (r = -0.40, p = 0.04). In the two obese patients, the response to the GHRP-2-load test markedly improved by weight loss 12 months after LSG. In conclusion, GH secretion was decreased in obese patients and improved by LSG.
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