Study summary · research use only
[EVALUATION OF GENOMIC PARAMETERS IN DUCTAL BREAST CANCER PATIENTS AND THE ABILITY OF IT'S CORRECTION]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study examined DNA single strand breaks, chromosomal abnormalities, and sister chromatid exchanges in lymphocyte cultures from human patients with ductal breast cancer, and tested whether these could be reduced using the oligopeptide bioregulator Livagen and cobalt ions. The genome of ductal breast cancer patients was characterized by a high density of DNA single strand breaks, a high frequency of chromosomal abnormalities, and increased chromatin condensation. Use of Livagen and cobalt as modifying agents was associated with a protective effect across the parameters studied. The authors suggest that lymphocyte analysis of this kind in ductal breast cancer patients could be useful in assessing treatment response in these patients.
Abstract
The level of DNA single strand breaks, chromosomal abnormalities and sister chromatid exchanges and the possibility of its normalization with oligopeptide bioregulator Livagen and cobalt ions in the lymphocyte culture from patients with breast cancer have been studied. The results show that the genome of ductal breast cancer patients is characterized by the high density of DNA single strand breaks, high frequency of chromosomal abnormalities and increased levels of chromatin condensation. The usage of Livagen and cobalt in the form of modifying agents has a protective effect by all studied parameters. The obtained results allow us to conclude that research of lymphocytes of ductal breast cancer patients using the analysis conducted by us, can be useful in assessing the therapeutic effect in the treatment of breast cancer patients.
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