Study summary · research use only
Interventional treatments for Hailey-Hailey disease
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review article (species: human) discusses interventional treatments reported for Hailey-Hailey disease (familial benign chronic pemphigus), a rare blistering skin condition affecting skin folds. For cases described as extensive and resistant to conventional therapy, the review lists laser ablation, photodynamic therapy, electron beam radiotherapy, botulinum toxin type A, dermabrasion, glycopyrrolate, and afamelanotide as treatments reported in the literature, while noting comparative trials are lacking. The article summarizes these treatment modalities along with the evidence described for the treatments most frequently discussed in the literature.
Abstract
Hailey-Hailey disease or familial benign chronic pemphigus is a rare blistering dermatosis that is characterized by recurrent erythematous plaques with a predilection for the skin folds. For extensive Hailey-Hailey disease that is recalcitrant to conventional therapy, laser ablation, photodynamic therapy, electron beam radiotherapy, botulinum toxin type A, dermabrasion, glycopyrrolate, and afamelanotide have been reported as useful treatments, but comparative trials are lacking. This review discusses the various treatment modalities for Hailey-Hailey disease and a summary of the evidence for the most recommended treatments.
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