Study summary · research use only
[Inhibiting effect of thymogen on the development of tumors of the esophagus and forestomach induced by N-nitrososarcosine ethyl ester in rats]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study, male rats received N-nitrososarcosine ethyl ester (NSEE) orally at 100 mg/kg body weight daily for 8 weeks to induce esophageal and forestomach tumors. After stopping the carcinogen, rats were treated for 32 weeks with either thymogen (an analog of the thymus polypeptide drug thymalin) at 10 micrograms per rat daily, or the immune-inactive polypeptide pulmolin at 0.5 mg per rat daily, and animals were killed 40 weeks after the start of the experiment. NSEE induced esophageal and forestomach tumors, mainly papillomas and occasional carcinomas, in nearly all rats, averaging more than 5 tumours per rat. The abstract reports thymogen decreased tumor incidence by 12% and reduced tumor multiplicity to 1.7 times as low, while pulmolin did not affect development of these tumors.
Abstract
Immunostimulating synthetic peptide thymogen being an analog of the thymus polypeptide drug thymalin was studied for its effect on carcinogenesis of the esophagus and forestomach in male rats. Rats received N-nitrososarcosine ethyl ester (NSEE) per os in the daily dose of 100 mg/kg of body weight during 8 weeks. After cessation of the carcinogen administration rats were treated with thymogen (the daily dose of 10 micrograms per rat) or immune-inactive polypeptide drug pulmolin from the alveolar tissue of lung (the daily dose of 0.5 mg per rat) during the following 32 weeks. Animals were killed 40 weeks after the experiment beginning. NSEE induced the esophagus and forestomach tumours, mainly papillomas and rarely carcinomas, practically in all rats, more than 5 tumours per rat, on the average. Thymogen decreased the tumour incidence by 12% and made tumour multiplicity 1.7 times as low. Pulmolin did not influence development of these tumours.
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