Study summary · research use only
The neurobiology of acetyl-L-carnitine
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses dietary supplementation of acetyl-L-carnitine (ALC), the principal acetyl ester of L-carnitine, and its reported role in intermediary metabolism as a donor of acetyl groups facilitating fatty acid transfer from cytosol to mitochondria during beta-oxidation (species not specified). The review states ALC supplementation is associated with effects described as neuroprotective, neurotrophic, antidepressive, and analgesic in painful neuropathies, along with antioxidant and anti-apoptotic activity, and reported effects on mitochondrial metabolism and gene expression in the central nervous system. The abstract states the review covers current knowledge of ALC's effects in the nervous system, including neuromodulatory effects on synaptic morphology and transmission.
Abstract
A large body of evidence points to the positive effects of dietary supplementation of acetyl-L-carnitine (ALC). Its use has shown health benefits in neuroinflammation, which is a common denominator in a host of neurodegenerative diseases. ALC is the principal acetyl ester of L-Carnitine (LC), and it plays an essential role in intermediary metabolism, acting as a donor of acetyl groups and facilitating the transfer of fatty acids from cytosol to mitochondria during beta-oxidation. Dietary supplementation of ALC exerts neuroprotective, neurotrophic, antidepressive and analgesic effects in painful neuropathies. ALC also has antioxidant and anti-apoptotic activity. Moreover, ALC exhibits positive effects on mitochondrial metabolism, and shows promise in the treatment of aging and neurodegenerative pathologies by slowing the progression of mental deterioration. In addition, ALC plays neuromodulatory effects on both synaptic morphology and synaptic transmission. These effects are likely due to affects of ALC through modulation of gene expression on several targets in the central nervous system. Here, we review the current state of knowledge on effects of ALC in the nervous system.
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