Study summary · research use only
[PTH preparations]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review describes parathyroid hormone (PTH) and its role in serum calcium regulation, noting that persistent excessive PTH action increases bone resorption and causes cortical bone loss, whereas intermittent PTH injections increase trabecular bone mainly by enhancing bone formation. Teriparatide, a peptide of 34 amino acids corresponding to the N-terminal portion of PTH, is discussed; the abstract reports that once daily and once weekly subcutaneous teriparatide injections are available in Japan, that teriparatide administration was associated with prevention of vertebral fractures, and that once daily injections were also associated with reduced non-vertebral fractures. The authors state that several questions about the precise mechanisms of action of teriparatide preparations remain unanswered. Species not specified.
Abstract
Parathyroid hormone(PTH) is essential for maintaining serum calcium level. PTH increases serum calcium partly by enhancing bone resorption. Therefore, persistent excessive actions of PTH result in cortical bone loss by increased bone resorption. In contrast, intermittent injections of PTH preparations increase trabecular bone mainly by enhancing bone formation. Teriparatide is a peptide with 34 amino acids corresponding to the N-terminal portion of PTH. Both once daily and once weekly subcutaneous injections of teriparatide are available in Japan. Teriparatide was shown to prevent vertebral fractures. In addition, once daily injections of teriparatide also reduce non-vertebral fractures. However, there still remain several unanswered questions about the precise mechanisms of actions of teriparatide preparations.
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