Study summary · research use only
[POLYPEPTIDES INFLUENCE ON TISSUE CELL CULTURES REGENERATION OF VARIOUS AGE RATS]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study, the authors compared polypeptides extracted from calf tissues, Cortexin (brain cortex), Epinorm (pineal gland), Ventvil (liver), Prostatilen (prostate), Thymalin (thymus), Chelohart (heart), Chondrolux (cartilage), on organotypic tissue cultures from young and old rats at concentrations of 0,01-100 ng/ml. The abstract reports that the polypeptides specifically stimulated growth of 'young' and 'old' cell cultures at 20-50 ng/ml, correlating with increased PCNA and decreased p53 expression in brain cortex, pineal gland, liver, prostate, heart and cartilage, and that Thymalin activated CD5 and CD20 expression, markers of B-cell differentiation. The authors conclude the tissue-derived polypeptides have selective molecular activity on regeneration of corresponding tissues in aging.
Abstract
A comparative study of polypeptides extracted from the tissues of calves: Cortexin (from brain cortex), Epinorm (from pineal gland), Ventvil (from liver), Prostatilen (from prostate), Thymalin (from thymus), Chelohart (from heart), Chondrolux (from cartilage) on the relevant organotypic tissue cultures of young and old rats, in concentration 0,01-100 ng/ml was performed. Polypeptides specifically stimulated "young" and "old" cell cultures growth in concentration 20-50 ng/ml. This effect correlates with increasing of PCNA and decreasing of p53 expression in brain cortex, pineal gland, liver, prostate, heart, cartilage. Moreover, Thymalin activated CD5, CD20 expression--markers of B-cells differentiation. These data show that polypeptides isolated from different tissues have selective molecular activity on the regeneration of suitable tissues in aging.
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