Study summary · research use only
The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses vasoactive intestinal peptide (VIP), a major immunoregulatory neuropeptide distributed in the central and peripheral nervous system. The abstract notes that besides neurones, VIP is synthesized by immune cells that also express VIP receptors, and reviews current information on VIP production and VIP-receptor-mediated effects in the immune system, the roles of endogenous and exogenous VIP in inflammatory and autoimmune disorders, and present and future VIP therapeutic approaches.
Abstract
Neuropeptides represent an important category of endogenous contributors to the establishment and maintenance of immune deviation in the immune-privileged organs such as the CNS and in the control of acute inflammation in the peripheral immune organs. Vasoactive intestinal peptide (VIP) is a major immunoregulatory neuropeptide widely distributed in the central and peripheral nervous system. In addition to neurones, VIP is synthesized by immune cells which also express VIP receptors. Here, we review the current information on VIP production and VIP-receptor-mediated effects in the immune system, the role of endogenous and exogenous VIP in inflammatory and autoimmune disorders and the present and future VIP therapeutic approaches.
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