Study summary · research use only
FoxO3a and disease progression
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses the Forkhead box O (FoxO) family as transcriptional regulators, noting that FoxO1, FoxO3a, FoxO4 and FoxO6 have been identified in humans. The abstract states FoxO3a has been studied extensively for its role in cell proliferation, apoptosis, metabolism, stress management and longevity, and that FoxO3a alteration is closely linked to progression of several cancers, fibrosis and other diseases. The authors examine FoxO3a's function in disease progression and its regulatory mechanisms and discuss it as a potential treatment target.
Abstract
The Forkhead box O (FoxO) family has recently been highlighted as an important transcriptional regulator of crucial proteins associated with the many diverse functions of cells. So far, FoxO1, FoxO3a, FoxO4 and FoxO6 proteins have been identified in humans. Although each FoxO family member has its own role, unlike the other FoxO families, FoxO3a has been extensively studied because of its rather unique and pivotal regulation of cell proliferation, apoptosis, metabolism, stress management and longevity. FoxO3a alteration is closely linked to the progression of several types of cancers, fibrosis and other types of diseases. In this review, we will examine the function of FoxO3a in disease progression and also explore FoxO3a's regulatory mechanisms. We will also discuss FoxO3a as a potential target for the treatment of several types of disease.
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