Study summary · research use only
Advancing or postponing the day of human chorionic gonadotropin does not matter for the outcome in assisted reproductive technology
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this retrospective study at a university infertility clinic, the authors examined whether the day of human chorionic gonadotropin (hCG) administration affects follicular response in assisted reproduction. Controlled ovarian hyperstimulation in 94 patients (2010-2011) with recombinant follicle stimulating hormone and a gonadotropin-releasing hormone antagonist was analyzed for hCG given on days 8-11. The abstract reports the average number of follicles larger than 18 mm did not differ significantly by day, but oocyte recovery rate (54.2%), mature oocytes (92.5%), and fertilization rate (78.5%) were maximum when hCG was given on day 8. The authors conclude weekend oocyte retrieval can be avoided by delaying or advancing hCG without compromising outcome.
Abstract
The primary outcome is to remove the worry of getting immature oocytes with early administration of human chorionic gonadotropin (hCG). The aim was to find out the association between the day of hCG administration and follicular response in relation to the number and maturity of oocytes, and fertilization rate in assisted reproduction to avoid weekend oocyte recovery (OR). Retrospective study was carried out in the university infertility clinic. Controlled ovarian hyperstimulation (COH) in 94 patients undergoing assisted reproductive technology (2010-2011) with recombinant follicle stimulating hormone and timely gonadotropin-releasing hormone antagonist were analyzed regarding day of hCG from day 8-11. Oocyte maturity and fertilization was analyzed and correlated with the day of hCG administration. Kruskal-Wallis test. The average number of >18 mm follicles observed from day 8-11 of hCG administration was not statistically different. However, the OR rate (54.2%), number of mature oocytes (92.5%), and fertilization rate (78.5%) was maximum in the patients where hCG was administered on day 8 of COH. The day of hCG administration between 8 and 11 does not affect the OR rate significantly although the number of oocytes recovered on day 8 are marginally higher compared with day 9-11. Hence, it is possible to safely avoid weekend oocyte retrieval, by delaying or advancing hCG administration without compromising the outcome.
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